This has been circulating for months, (a year, even?) so my comments are beyond late. But anyway:
It's a cute joke. And it's right. But the meme only really works if you assume that Gaga's being totally sincere.
Now, I don't think she's being insincere. She's telling kids that they weren't born 'wrong', that they're aren't mistakes by virtue of being different than the norm. It's pretty basic stuff, but that's the audience it was written for, too - adolescents that have never heard of queer theory, kids in Middle America who aren't hearing this message from anyone else.
And seriously? Look at that picture. She has prosthetic spiky cheekbones and horns. I'm willing to guess that she wasn't actually born that way.